2. Neurological Disease

Neurological Disease

Neurological Disease

Related Products

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-103185R
    CCPA (Standard) 37739-05-2 98%
    CCPA (2-Chloro-N6-cyclopentyladenosine (Standard)) is the analytical standard of CCPA (HY-103185). This product is intended for research and analytical applications. CCPA (2-Chloro-N6-cyclopentyladenosine) a highly selective A1 adenosine receptors agonist with a Ki of 0.4 nM. CCPA inhibits adenylate cyclase with an IC50 of 33 nM. CCPA exhibits anti-seizure and cardiacprotective activity. CCPA can be used for the research of seizure and myocardial infarction.
    CCPA (Standard)
  • HY-103190R
    MRS1220 (Standard) 183721-15-5
    MRS1220 (Standard) is the analytical standard of MRS1220 (HY-103190). This product is intended for research and analytical applications. MRS1220, a highly potent and selective human A3 adenosine receptor (hA3AR) antagonist with a Ki of 0.59 nM, has therapeutic potential for the research of diseases of the central nervous system. MRS1220 reduces glioblastoma tumor size and blood vessel formation in vivo.
    MRS1220 (Standard)
  • HY-103192R
    MDL12330A (Standard) 40297-09-4 98%
    MDL12330A (Standard) is the analytical standard of MDL12330A (HY-103192). MDL12330A (RMI12330A) is an adenylyl cyclases inhibitor. MDL12330A can inhibit KV channels, increases insulin secretion and Ca2+ levels. MDL12330A accentuates contractions in uterine rings and inhibits cardiac functions. MDL12330A can be used for the research of endocrinology, metabolic and cardiovascular disease .
    MDL12330A (Standard)
  • HY-103197R
    2-Methoxyidazoxan monohydrochloride (Standard) 109544-45-8 98%
    2-Methoxyidazoxan (monohydrochloride) (Standard) is the analytical standard of 2-Methoxyidazoxan (monohydrochloride). This product is intended for research and analytical applications. 2-Methoxyidazoxan monohydrochloride (RX821002 hydrochloride) is a highly selective alpha 2-adrenoceptor antagonist with little or no imidazoline antagonist effect. RX 821002 has markedly higher affinity for (guinea-pig) alpha 2D-adrenoceptors (pKd 9.7) than for (rabbit) alpha 2A-adrenoceptors (pKd 8.2).
    2-Methoxyidazoxan monohydrochloride (Standard)
  • HY-103203R
    ST91 (Standard) 4749-61-5
    ST91 (Standard) is the analytical standard of ST91 (HY-103203). This product is intended for research and analytical applications. ST91 is a α2-adrenoceptor (α2AR) agonist. ST91 activates both α2AAR and non-α2AAR subtypes to produce spinal antinociception.
    ST91 (Standard)
  • HY-103210R
    DSP-4 hydrochloride (Standard) 40616-75-9 98%
    DSP-4 hydrochloride (Standard) is the analytical standard of DSP-4 hydrochloride (HY-103210). This product is intended for research and analytical applications. DSP-4 hydrochloride is a highly and selective adrenergic neurotoxin. DSP-4 hydrochloride can cross the blood brain barrier. DSP-4 hydrochloride can be used for the temporary selective degradation of the central and peripheral noradrenergic neurons.
    DSP-4 hydrochloride (Standard)
  • HY-103213R
    JP1302 dihydrochloride (Standard) 1259314-65-2 98%
    JP1302 dihydrochloride (Standard) is the analytical standard of JP1302 dihydrochloride. This product is intended for research and analytical applications. JP1302 dihydrochloride is a potent, selective, high affinity antagonist of the α2C-adrenoceptor, with a Kb of 16 nM and a Ki of 28 nM for the human α2C-receptor. JP1302 dihydrochloride shows antidepressant and antipsychotic-like effects. JP1302 dihydrochloride can be used for neuropsychiatric disorders and renal dysfunction research.
    JP1302 dihydrochloride (Standard)
  • HY-103220R
    6,2',4'-Trimethoxyflavone (Standard) 720675-74-1
    6,2',4'-Trimethoxyflavone (Standard) is the analytical standard of 6,2',4'-Trimethoxyflavone (HY-103220). This product is intended for research and analytical applications. 6,2',4'-Trimethoxyflavone is a potent aryl hydrocarbon receptor (AHR) antagonist. 6,2',4'-Trimethoxyflavone represses AHR-mediated gene induction.
    6,2',4'-Trimethoxyflavone (Standard)
  • HY-103228R
    GYKI 53655 hydrochloride (Standard) 143692-48-2 98%
    GYKI 53655 hydrochloride (Standard) is the analytical standard of GYKI 53655 hydrochloride (HY-103228). This product is intended for research and analytical applications. GYKI 53655 (LY300168) hydrochloride is an α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) antagonist.
    GYKI 53655 hydrochloride (Standard)
  • HY-103230R
    IEM-1460 (Standard) 121034-89-7
    IEM-1460 (Standard) is the analytical standard of IEM-1460 (HY-103230). This product is intended for research and analytical applications. IEM-1460 blocks both AMPA and NMDA glutamate receptor with anticonvulsant effect in vivo.
    IEM-1460 (Standard)
  • HY-103237R
    L-Adenosine (Standard) 3080-29-3
    L-Adenosine (Standard) is the analytical standard of L-Adenosine (HY-103237). This product is intended for research and analytical applications. L-Adenosine is a metabolically stable enantiomeric analog and also is a potential probe. L-Adenosine has weakly inhibitory adenosine deaminase (ADA) activity with an Ki value of 385 μM. L-Adenosine can be used for the research of adenosine uptake and accumulation.
    L-Adenosine (Standard)
  • HY-103238R
    RSVA405 (Standard) 140405-36-3
    RSVA405 (Standard) is the analytical standard of RSVA405 (HY-103238). This product is intended for research and analytical applications. RSVA405 is a potent, orally active activator of AMPK, with an EC50 of 1 μM. RSVA405 facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR, and promotes autophagy to increase Aβ degradation. RSVA405 has anti-inflammatory effects through the inhibition of STAT3 function. RSVA405 can also be used for the research of obesity.
    RSVA405 (Standard)
  • HY-103241R
    Ro 90-7501 (Standard) 293762-45-5
    Ro 90-7501 (Standard) is the analytical standard of Ro 90-7501 (HY-103241). This product is intended for research and analytical applications. Ro 90-7501 is an amyloid β42 (Aβ42) fibril assembly inhibitor that reduces Aβ42-induced cytotoxicity (EC50 of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response. Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner. Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells.
    Ro 90-7501 (Standard)
  • HY-103253R
    LY231617 (Standard) 141545-89-3
    LY231617 (Standard) is the analytical standard of LY231617 (HY-103253). This product is intended for research and analytical applications. LY231617 is a potent and blood-brain barrier penetrable antioxidant. LY231617 is a neuroprotective agent in brain, it can be used for the research of nervous disease.
    LY231617 (Standard)
  • HY-103254R
    ML221 (Standard) 877636-42-5
    ML221 (Standard) is the analytical standard of ML221 (HY-103254). This product is intended for research and analytical applications. ML221 is a potent apelin (APJ) functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC80 of 10 nM in both assays.
    ML221 (Standard)
  • HY-103263R
    PSB-06126 (Standard) 1052089-16-3
    PSB-06126 (Standard) is the analytical standard of PSB-06126 (HY-103263). This product is intended for research and analytical applications. PSB-06126 is a selective nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with the Ki values of 0.33 μM for rat NTPDase 1, 19.1 μM for NTPDase 2 and 2.22 μM for NTPDase 3, respectively. PSB-06126 acts on human NTPDase 3 with an IC50 value of 7.76 μM and a Ki value of 4.39 μM.
    PSB-06126 (Standard)
  • HY-103293B
    Lys-Bradykinin tetraacetate 84640-50-6 98%
    Lys-Bradykinin (Kallidin (380-389) (human, porcine, bovine)) tetraacetate, a kind of kallidin and bradykinin receptor ligand, can be generated by kininogen protein through enzymatic cleavage by the protease kallikrein. Lys-Bradykinin tetraacetate, also a vasodilator, can widen blood vessels and increase blood flow. ys-Bradykinin stimulates net Na+ influx, and also the DNA synthesis. Lys-Bradykinin tetraacetate involves in vascular regulation, inflammation and pain sensation.
    Lys-Bradykinin tetraacetate
  • HY-103308R
    TRAM-39 (Standard) 197525-99-8 98%
    TRAM-39 (Standard) is the analytical standard of TRAM-39 (HY-103308). This product is intended for research and analytical applications. TRAM-39 is a selective blocker of intermediate conductance Ca2+-activated K+ (IKCa) channels. TRAM-39 inhibits KCa3.1 channel with an IC50 value of 60 nM. TRAM-39 can be used for the research of ataxia, epilepsy, memory disorders, schizophrenia and Parkinson’s disease.
    TRAM-39 (Standard)
  • HY-103309R
    ML218 (Standard) 1346233-68-8
    ML218 (Standard) is the analytical standard of ML218 (HY-103309). This product is intended for research and analytical applications. ML218 is a potent, selective and orally active T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC50s of 310 nM and 270 nM for Cav3.2 and Cav3.3, respectively. ML218 inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 has no significant inhibition of L- or N-type calcium channels, KATP or hERG potassium channels. ML218 can penetrate the blood-brain barrier.
    ML218 (Standard)
  • HY-103319R
    Calmidazolium chloride (Standard) 57265-65-3 98%
    Calmidazolium chloride (Standard) is the analytical standard of Calmidazolium chloride (HY-103319). This product is intended for research and analytical applications. Calmidazolium chloride (R 24571) is a calmodulin antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC50s of 0.15 and 0.35 μM, respectively. Also in anti-cancer research. Calmidazolium binds to calmodulin with a Kd of 3 nM.
    Calmidazolium chloride (Standard)
Cat. No. Product Name / Synonyms Application Reactivity